CONGRESS 2023 - Narcolepsy and its association with HLA type

This presentation will introduce basic sleep physiology related to the pathophysiological mechanisms Narcolepsy is a rare but debilitating neurological sleep disorder, with a worldwide prevalence of 25-50 per 100,000 people. Onset is most common during the adolescent years, though a diagnostic delay of around 10 years is common. There is currently no cure, though symptoms can be managed using pharmacotherapy. Biochemistry services provide an important role in confirming a diagnosis of narcolepsy in line with current international guidelines such as the International Classification of Sleep Disorders 3rd edition (ICSD-3). The aims of this talk are to: 1. Introduce basic sleep physiology related to the pathophysiological mechanisms underpinning narcolepsy. 2. To describe the signs and symptoms of narcolepsy and their impact on patients. 3. To review the diagnosis of narcolepsy including the role of biomarkers such as HLA type and CSF hypocretin. 4. To summarise treatment options for narcolepsy.

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