CONGRESS 2023 - A practical guide to serum free light chains – technical challenges and clinical utility
The analysis of free light chains in clinical laboratories to support the diagnosis and treatment monitoring of Myeloma has evolved over 6 decades. From urine analysis for Bence Jones Protein using gel electrophoresis in the 1950s to the launch of the first commercial assay for serum free light chain measurement in 2001. This talk will describe the biochemistry of free light chains and the benefits and challenges of the different methodologies available in laboratories today. I will also describe the complexity of clinical interpretation of results, highlighting relevant national guidance, recently developed diagnostic tools for clinicians and testing advice for laboratories.
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Learning outcomes
Delegates will understand:
- What are free light chains
- Monoclonal v’s polyclonal free light chains
- Why we measure free light chains by different methods
- The laboratory methods we use for measurement
- The pros and cons of immunoassay and electrophoresis free light chain measurements
- The clinical relevance of results