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CONGRESS 2023 - Lassa fever virus & emerging mammarenaviruses

28/09/2023
The Arenaviridae have the dubious distinction of containing among their members one of greatest proportions of hazard group 4 viruses of any recognised taxonomic family. These viruses cause persistent asymptomatic infections in their rodent reservoirs, however zoonotic spill over often results in viral haemorrhagic fever (VHF) and high mortality. Transmission to humans occurs via contact with infected rodent excreta, through contaminated food and inhalation of aerosols. Human to human transmission also occurs. In sub-Sharan West Africa, Lassa virus (LASV) has been identified as a VHF since 1969 and is endemic over much of rural Nigeria, the countries of Mano River Union, Ghana, Togo and Benin.

From a global health security perspective, it is of significant international interest since it the most commonly imported VHF into non-endemic countries. In nearly every imported circumstance, the cryptic nature of Lassa fever and related difficulties in diagnosis, places enormous demand on clinical, laboratory and public health resources of the recipient country. Given our current understanding of LASV and other evolving members of the genus, attention should be focused on other new and emerging mammarenaviruses which have similar incubation times and could result in similar human disease with a propensity to overburden public health systems.

CONGRESS 2023 - Managing the Human Tissue Authority inspection and selected case studies

28/09/2023
I wish to offer a practical guide to working with the Human Tissue Authority.



I will provide examples of what to do and how to do it when issues arise



I will take you through the paperwork involved

I will describe how best to approach HTA reportable incidents

I will take you through how to prepare for the HTA inspection

This will be a very hands on guide and strongly welcome participation from the audience.

CONGRESS 2023 - Meet the Examiner Session

28/09/2023
Meet the Examiner Session

CONGRESS 2023 - Meet the Microbiology Experts

28/09/2023
Meet the Microbiology Experts

CONGRESS 2023 - National Point-of-Care Strategy

28/09/2023
National Point-of-Care Strategy

CONGRESS 2023 - New drugs for bad bugs: What’s in the pipeline?

28/09/2023
Increasing antimicrobial resistance observed globally in key Gram-negative bacteria and failure of the antimicrobial development pipeline to keep up has left clinicians with few remaining treatment options. This presentation will: i) highlight the current gaps in our antimicrobial armamentarium (with a focus on the World Health Organisation critical priority pathogens); ii) give an overview of new antimicrobials that have reached phase 3 clinical trials and other therapeutic approaches currently in the pipeline; and iii) share experience from the reference laboratory.

CONGRESS 2023 - Pandemics – Past (polio; smallpox; Ebola)

28/09/2023
This lecture will overview previous viral pandemics affecting humans and highlight lessons learned (or not). This lecture will provide the audience with background information relevant to the two subsequent talks on pandemics currently affecting and what might come next. At the end of this talk the audience will have knowledge on some major pathogenic viruses that have impacted hugely on the human population including:

Smallpox; influenza; polio; yellow fever; HIV and Ebola that bring us up to the novel coronavirus outbreaks that have plagued mankind during more recent years.

CONGRESS 2023 - Pandemics Present

28/09/2023
Pandemics Present

CONGRESS 2023 - Pathogen detection & chronic lung infection underestimated in cystic fibrosis

28/09/2023
Chronic lung infection is the leading cause of morbidity and early mortality for people with cystic fibrosis (pwCF). Microbiological surveillance to detect lung pathogens is recommended as best practise in CF patient care. Here we studied pathogen detection in forty pwCF over several years. We found that microbiological culture, the diagnostic gold standard, was significantly disparate to targeted culture-independent approaches for detection and determination of chronic infection status of two important pathogens in CF. Pathogen detection was significantly lower by culture and consequently infection status was also misclassified in the majority of cases.

In particular, the extent of chronic infection by both Pseudomonas aeruginosa and Staphylococcus aureus not realised with culture was striking. Our findings have implications for the development of infection and clinical care of pwCF. Future longitudinal studies with greater patient numbers will be needed to establish the full extent of the clinical implications indicated from this study.

CONGRESS 2023 - Pets to pandemics – viral zoonoses

28/09/2023
It is clear that the interaction of humans with animals and the environment has been at the centre of infectious disease emergence and spread through out history. Recent global events have shown that this is still the case, or at least likely to be! Close contact with animals and our collective movements in and out of each others environments has the potential to permit transmission of organisms that have the potential to cause zoonotic or indeed enzoonotic disease. We need to consider this aspect carefully to understand what mitigations we might need to put into place and also what considerations might need to be taken on board in the light of changes to infection patterns as a possible consequence of climate change.
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